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1

Gq/11 and Gi/o activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype

Elizabeth C Akam, R A John Challiss, Stefan R Nahorski

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 208 KB

english, 2001

2

Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences

Stefan R. Nahorski, C. Ian Ragan, R.A.John Challiss

Journal:

Trends in Pharmacological Sciences

Year:

1991

Language:

english

File:

PDF, 1.07 MB

english, 1991

3

Identification and significance of beta-adrenoceptor subtypes

Stefan R. Nahorski

Journal:

Trends in Pharmacological Sciences

Year:

1981

Language:

english

File:

PDF, 418 KB

english, 1981

4

Synthetic D- and L-enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate interact differently with myo-inositol 1,4,5-trisphosphate binding proteins: Identification of a potent small molecule 3-kinase inhibitor

Stephen T. Safrany, Deborah A. Sawyer, Stefan R. Nahorski, Barry V.L. Potter

Journal:

Year:

1992

Language:

english

File:

PDF, 684 KB

english, 1992

5

The role of the 2- and 3-hydroxyl groups of 1d-myo-inositol 1,4,5-trisphosphate in the mobilisation of calcium from permeabilised human 1321N1 astrocytoma cells

Robert A. Wilcox, Stefan R. Nahorski, Deborah A. Sawyer, Changsheng Liu, Barry V.L. Potter

Journal:

Carbohydrate Research

Year:

1992

Language:

english

File:

PDF, 707 KB

english, 1992

6

Synthesis from quebrachitol of 1l-chiro-inositol 2,3,5-trisphosphate, an inhibitor of the enzymes of 1d-myo-inositol 1,4,5-trisphosphate metabolism

Changsheng Liu, Stefan R. Nahorski, Barry V.L. Potter

Journal:

Carbohydrate Research

Year:

1992

Language:

english

File:

PDF, 711 KB

english, 1992

7

Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

Abdul H. Fauq, Javid H. Zaidi, Robert A. Wilcox, Girlie Varvel, Stefan R. Nahorski, Alan P. Kozikowski, Christophé Erneux

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 250 KB

english, 1996

8

Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 — potent 1d-1,4,5-InsP3-like calcium mobilizing analogues

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 321 KB

english, 1995

9

Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate

Stephen J Mills, Stephen T Safrany, Robert A Wilcox, Stefan R Nahorski, Barry VL Potter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 343 KB

english, 1993

10

Synthesis of L-chiro-inositol 1,4,6-trisphosphorothioate, a potent and selective inhibitor of myo-inositol 1,4,5-trisphosphate 5-phosphatase

Changsheng Liu, Stephen T Safrany, Stefan R Nahorski, Barry VL Potter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 323 KB

english, 1992

11

Characterization of the metabotropic glutamate receptors mediating phospholipase C activation and calcium release in cerebellar granule cells: calcium-dependence of the phospholipase C response

Roser Masgrau, Joan-Marc Servitja, Kenneth W. Young, Raul Pardo, Elisabet Sarri, Stefan R. Nahorski, Fernando Picatoste

Journal:

European Journal of Neuroscience

Year:

2001

Language:

english

File:

PDF, 313 KB

english, 2001

12

Muscarinic Receptor-Mediated Inositol 1,4,5-Trisphosphate Formation in SH-SY5Y Neuroblastoma Cells Is Regulated Acutely by Cytosolic Ca2+ and by Rapid Desensitization

Richard J. H. Wojcikiewicz, Andrew B. Tobin, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 957 KB

english, 1994

13

Differential Effects of Lithium on Muscarinic Cholinoceptor-Stimulated CMP-Phosphatidate Accumulation in Cerebellar Granule Cells, CHO-M3 Cells, and SH-SY5Y Neuroblastoma Cells

David W. Gray, R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 757 KB

english, 1994

14

Chronic Activation of Muscarinic and Metabotropic Glutamate Receptors Down-Regulates Type I Inositol 1,4,5-Trisphosphate Receptor Expression in Cerebellar Granule Cells

Peter B. Simpson, R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 421 KB

english, 1994

15

Muscarinic Cholinoceptor-Stimulated Synthesis and Degradation of Inositol 1,4,5-Trisphosphate in the Rat Cerebellar Granule Cell

David W. Gray, Emma M. Whitham, R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 875 KB

english, 1995

16

Mobilization of Inositol 1,4,5-Trisphosphate-Sensitive Ca2+ Stores Supports Bradykinin- and Muscarinic-Evoked Release of [3H]Noradrenaline from SH-SY5Y Cells

John R. Purkiss, Stefan R. Nahorski, Gary B. Willars

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 824 KB

english, 1995

17

Agonist-Evoked Ca2+ Mobilization from Stores Expressing Inositol 1,4,5-Trisphosphate Receptors and Ryanodine Receptors in Cerebellar Granule Neurones

Peter B. Simpson, Stefan R. Nahorski, R. A. John Challiss

Journal:

Journal of Neurochemistry

Year:

1996

Language:

english

File:

PDF, 1.05 MB

english, 1996

18

Intracellular Ca2+ Stores Regulate Muscarinic Receptor Stimulation of Phospholipase C in Cerebellar Granule Cells

Roser Masgrau, Joan-Marc Servitja, Elisabet Sarri, Kenneth W. Young, Stefan R. Nahorski, Fernando Picatoste

Journal:

Journal of Neurochemistry

Year:

2000

Language:

english

File:

PDF, 158 KB

english, 2000

19

Enhanced inducible mGlu1α receptor expression in Chinese hamster ovary cells

Mark S. Nash, Julie V. Selkirk, Caroline E. Gaymer, R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 382 KB

english, 2001

20

Biogenic Amine-Stimulated Cyclic Adenosine-3′,5′-Monophosphate Formation in the Rat Carotid Body

Anis K. Mir, David J. Pallot, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1983

Language:

english

File:

PDF, 651 KB

english, 1983

21

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor Characterisation

Elaine Brown, David A. Kendall, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1984

Language:

english

File:

PDF, 859 KB

english, 1984

22

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: II. Calcium Requirement

David A. Kendall, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1984

Language:

english

File:

PDF, 627 KB

english, 1984

23

Differential Effects of Lithium on Muscarinic Receptor Stimulation of Inositol Phosphates in Rat Cerebral Cortex Slices

Ian Batty, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1985

Language:

english

File:

PDF, 700 KB

english, 1985

24

Specific Inhibition of Dopamine D-1-Mediated Cyclic AMP Formation by Dopamine D-2, Muscarinic Cholinergic, and Opiate Receptor Stimulation in Rat Striatal Slices

Eamonn Kelly, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1986

Language:

english

File:

PDF, 551 KB

english, 1986

25

Endogenous Dopamine Functionally Activates D-1 and D-2 Receptors in Striatum

Eamonn Kelly, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 575 KB

english, 1987

26

Dopamine Receptor Stimulation Does Not Affect Phosphoinositide Hydrolysis in Slices of Rat Striatum

Eamonn Kelly, Ian Batty, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1988

Language:

english

File:

PDF, 712 KB

english, 1988

27

Lithium Reduqes the Accumulation or Inositol Polyphosphate Second Messengers Following Cholinergic Stimulation of Cerebral Cortex Slices

Eleanor D. Kennedy, R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 412 KB

english, 1989

28

Dual Effects of K+ Depoiarisation on Inositol Polyphosphate Production in Rat Cerebral Cortex

John G. Baird, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 478 KB

english, 1989

29

Increased Intracellular Calcium Stimulates 3H-Inositol Polyphosphate Accumulation in Rat Cerebral Cortical Slices

John G. Baird, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 657 KB

english, 1990

30

Regulation of Muscarinic Agonist-Induced Activation of Phosphoinositidase C in Electrically Permeabilized SH-SY5Y Human Neuroblastoma Cells by Guanine Nucleotides

Richard J. H. Wojcikiewicz, David G. Lambert, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 1.03 MB

english, 1990

31

Neurotransmitter and Depolarization-Stimulated Accumulation of Inositol 1,3,4,5-Tetrakisphosphate Mass in Rat Cerebral Cortex Slices

R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 439 KB

english, 1990

32

Stimulatory and Inhibitory Effects of N-Methyl-D-Aspartate on 3H-Inositol Polyphosphate Accumulation in Rat Cortical Slices

John G. Baird, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 752 KB

english, 1991

33

Depolarization and Agonist-Stimulated Changes in Inositol 1,4,5-Trisphosphate and Inositol 1,3,4,5-Tetrakisphosphate Mass Accumulation in Rat Cerebral Cortex

R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 1.04 MB

english, 1991

34

Inositol 1,4,5-Trisphosphate Receptor Immunoreactivity in SH-SY5Y Human Neuroblastoma Cells Is Reduced by Chronic Muscarinic Receptor Activation

Richard J. H. Wojcikiewicz, Shinji Nakade, Katsuhiko Mikoshiba, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1992

Language:

english

File:

PDF, 507 KB

english, 1992

35

Involvement of Intracellular Stores in the Ca2+ Responses to N-Methyl-D-Aspartate and Depolarization in Cerebellar Granule Cells

Peter B. Simpson, R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 430 KB

english, 1993

36

Comparative Effects of Lithium on the Phosphoinositide Cycle in Rat Cerebral Cortex, Hippocampus, and Striatum

Stephen Jenkinson, Neela Patel, Stefan R. Nahorski, R. A. John Challiss

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 948 KB

english, 1993

37

Characterisation and Distribution of Inositol Polyphosphate and Ryanodine Receptors in the Rat Brain

Susan M. Smith, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 977 KB

english, 1993

38

NMDA-receptor regulation of muscarinic-receptor stimulated inositol 1,4,5-trisphosphate production and protein kinase C activation in single cerebellar granule neurons

Kenneth W. Young, M. Asier Garro, R. A. John Challiss, Stefan R. Nahorski

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 472 KB

english, 2004

39

Group I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to cyclic AMP response element binding protein (CREB) through a common Ca2+- and protein kinase C-dependent pathway

Helen K. Warwick, Stefan R. Nahorski, R. A. John Challiss

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 468 KB

english, 2005

40

The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons

Jonathon M. Willets, Carl P. Nelson, Stefan R. Nahorski, R. A. John Challiss

Journal:

Journal of Neurochemistry

Year:

2007

Language:

english

File:

PDF, 519 KB

english, 2007

41

Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons

Carl P. Nelson, Stefan R. Nahorski, R. A. John Challiss

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 843 KB

english, 2008

42

10.1038/35096643

Nash, Mark S., Young, Kenneth W., John Challiss, R. A., Nahorski, Stefan R.

Journal:

Year:

2001

Language:

english

File:

PDF, 157 KB

english, 2001

43

Pharmacological characterization of type 1α metabotropic glutamate receptor-stimulated [35S]-GTPγS binding

Elizabeth C Akam, Alan M Carruthers, Stefan R Nahorski, R A John Challiss

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 380 KB

english, 1997

44

Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus

Donna K Boxall, Anthony P D W Ford, Agnes Choppin, Stefan R Nahorski, R A John Challiss, Richard M Eglen

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 314 KB

english, 1998

45

Effects of varying the expression level of recombinant human mGlu1α receptors on the pharmacological properties of agonists and antagonists

Emmanuel Hermans, R A John Challiss, Stefan R Nahorski

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 427 KB

english, 1999

46

Complex relationship between Ins(1,4,5)P3 accumulation and Ca2+-signalling in a human neuroblastoma revealed by cellular differentiation

Amanda K Martin, Stefan R Nahorski, Gary B Willars

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 183 KB

english, 1999

47

Pharmacology of intracellular signalling pathways

Stefan R Nahorski

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 276 KB

english, 2006

48

Neurochemical and behavioural evidence that dopamine D-2 receptors in striatum couple to the Niregulatory protein and inhibition of cyclic AMP accumulation

Eamonn Kelly, Alan L. Willcocks, Stefan R. Nahorski

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1987

Language:

english

File:

PDF, 883 KB

english, 1987

49

Dopamine D-2 receptors inhibit D-1 stimulated cyclic AMP accumulation in striatum but not limbic forebrain

Eamonn Kelly, Stefan R. Nahorski

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1987

Language:

english

File:

PDF, 498 KB

english, 1987

50

Investigations of the roles of dihydropyridine and ω-conotoxin-sensitive calcium channels in mediating depolarisation-evoked endogenous dopamine release from striatal slices

Hugh Herdon, Stefan R. Nahorski

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1989

Language:

english

File:

PDF, 518 KB

english, 1989